Protein Details: Potassium voltage-gated channel subfamily H member 7

Protein ID

ICDB_Pro_1479

Protein Name

Potassium voltage-gated channel subfamily H member 7

Gene Name

Kcnh7; Erg3

Organism

Mus musculus (Mouse)

Length

1195 amino acids

AlphaFoldDB

AF-Q9ER47-F1-model_v4.pdb

Function

Pore-forming (alpha) subunit of voltage-gated potassium channel (By similarity). Channel properties may be modulated by cAMP and subunit assembly

Sequence

MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAMMFIINFEYVTDEENAATPERVNPILPVKTVNRKLFGFKFPGLRVLTYRKQSLPQEDPDVVVIDSSKHSDDSVAMKHFKSPTKESCSPSEADDTKALIQPSQCSPLVNISGPLDHSSPKRQWDRLYPDMLQSSSQLTHSRSRESLCSIRRASSVHDIEGFSVHPKNIFRDRHASEDNGRNVKGPFNHIKSSLLGSTSDSNLNKYSTINKIPQLTLNFSDVKTEKKNTSPPSSDKTIIAPKVKERTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKIGWLDSLGTQIGKRYNDSDSSSGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFNLRHESAKSQSVNDSEGDTGKLRRRRLSFESEGEKDFSKENSANDADDSTDTIRRYQSSKKHFEERKSRSSSFISSIDDEQKPLFLGTVDSTPRMVKATRLHGEETMPHSGRIHTEKRSHSCRDITDTHSWEREPARAQPEECSPSGLQRAAWGVSETESDLTYGEVEQRLDLLQEQLNRLESQMTTDIQAILQLLQKQTTVVPPAYSMVTAGAEYQRPILRLLRTSHPRASIKTDRSFSPSSQCPEFLDLEKSKLQSKESLSSGRRLNTASEDNLTSLLKQDSDASSELDPRQRKTYLHPIRHPSLPDSSLSTVGILGLHRHVSDPGLPGK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

745..862

Disease

Location

DOI ID

10.1371/journal.pbio.1000112; 10.1016/j.cell.2010.12.001

RefSeq

NP_573470.2